DESIGN AND PRE-CLINICAL EVALUATION OF A UNIVERSAL HIV-1 VACCINE.

Design and pre-clinical evaluation of a universal HIV-1 vaccine.

BACKGROUND:One of the big roadblocks in development of HIV-1/AIDS vaccines is the enormous diversity of HIV-1, which could limit the value of any HIV-1 vaccine candidate currently under test.METHODOLOGY AND FINDINGS:To address the HIV-1 variation, we designed a novel T cell immunogen, designated HIV(CONSV), by assembling the 14 most conserved regio

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Surgical repair of a ruptured flexor hallucis longus tendon via tenoplasty and autogenous peroneus longus tendon graft

An isolated open rupture of the flexor hallucis longus tendon is an uncommon injury.We present a case of a chronic flexor hallucis longus rupture distal to the sesamoid complex in an active 12-year-old male after he stepped on a piece cubs foam finger of glass.Surgical repair involved a flexor hallucis longus adhesiotomy and tenoplasty with autogen

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